The Science and Technology Studies research group at Mexico’s National Autonomous University (UNAM) is a multi-disciplinary cluster that brings together scholars and students working in the history, philosophy, film & literature, cultural, feminist, and social studies of science, technology, and biomedicine. Situated in Mexico, in our research we engage methods spanning visual and laboratory ethnography, textual analysis, archival research, and participant observation. Throughout our investigative processes, whether in the field or the archive, we have encountered and experienced a number of interruptions. Rather than dismissing them as epistemic obstacles or methodological noise, our position as STSers in a postcolonial context has attuned us to recognize them as provocations that allow us to reposition and retool our approaches. In this exhibit we bring interruptions to the fore, instantiated as a 7.1 magnitude earthquake in Mexico City that abruptly ended a patient interview; the jarring image of a cancerous tumor laid out on a tray instead of pristine slides expected to find catalogued in a biobank; the itinerary of a mobile radioisotope unit disrupted by the crashing of its transport train; when Mexico’s context of violence and insecurity not only limits access to the field, but forcefully expels us from it.